If the subject line of the email is irrelevant to customers, they will ignore it multiple times. But, if it keeps repeating, they are intercepted and unsubscribed from your emails. So, send relevant emails for the benefit of the customer. Don't send emails that often only focus on sales, offers and discounts.
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That includes cuts to a significant number of science programmes such as the Mars Sample Return that aims to return samples from the planet's surface to Earth.